Phytochemical Analysis and Antibacterial Activity of Purple Leaf Extract [Graptophyllum pictum (L.) Griff] Against Streptococcus mutans

Background. Streptococcus mutans is the leading cause of dental caries. One many medicinal plants, purple leaf [Graptophyllum pictum (L.) Griff], which contains flavonoids, alkaloids, tannins, steroids, and saponins, a potential antibacterial agent.
 Objective. This study aimed to determine activity extract (Graptophyllum L. Griff) against mutans.
 Methods. were suspended in several Graptophyllum Griff concentrations BHIB medium using dilution method so that concentration 100%, 50%, 25%, 12.5%, 6.25%, 3.12%, 1.56%, 0.78% obtained. Each tube was incubated for 24 hours, then subcultured Tryptone Yeast Extract Cystine petri dish spreader. set hours; growth colony, CFU/mL unit, manually calculated. The samples subjected microbiological analysis. Tukey's Honest Significant Difference test performed if relationship between sets data treatment group statistically significant (p<0.05).
 Results. Purple bioactive compounds such as flavonoid, alkaloid, tannin, triterpenoid/ steroid, saponin. Minimum Inhibitory Concentration (MIC) 3.125%, Bactericidal (MBC) 6.25%.
 Conclusion. Leaf Griff] has mutans.